Research Advances

Orange County is the Silicon Valley of eye care not just in the United States, but for the entire world.

For over 45 years, Harvard Eye Associates has brought our patients the most advanced treatments and procedures in both medical and surgical eye care. We continue to conduct research on new lens implants, surgical devices, and medications before they are available to the general medical community.

Clinical Studies

For additional information about Harvard Eye Associates’ clinical trials, please visit

Below is a list of ongoing studies at Harvard Eye Associates:

Cataract Surgery

Sponsor: Ophthalmic Consultants of Long Island (OCLI)CIMPLIFY:

A Randomized Self-controlled Prospective Clinical Study Evaluating the Safety and Efficacy of a dropless intracanalicular insert delivery system of Dexamethasone, Intracameral Ketorolac, and Intracameral Moxifloxacin compared to traditional topical postoperative prednisolone Acetate, Moxifloxacin and Ketorolac in controlling post-operative pain and inflammation in subjects undergoing sequential bilateral cataract surgery.

Co-Investigator: John Hovanesian, MD

Sub Investigator: Isabell Choi, OD

Sponsor: Research InSight, LLC

Vivity Insight: A Study of Patient Satisfaction and Visual Performance

Principal Investigator: John Hovanesian, MD


Corneal Disease: Fuch’s Dystrophy

Sponsor: Aerie Pharmaceuticals, Inc

A Randomized, Open-Label, Parallel-Group Study to Evaluate the Safety and Efficacy of Two Dosing Regimens of Netarsudil Ophthalmic Solution in Patients with Corneal Edema Due to Fuchs Corneal Dystrophy.

Principal Investigator: John Hovanesian, MD

Sub Investigator: Behanz Rouhani, MD


Ocular Surface: Dry Eye Syndrome

Sponsor: Novartis

A Randomized, Double-Masked, Multicenter Study to Evaluate the Safety and Efficacy of ECF843 vs Vehicle in Subjects with Dry Eye Disease

Principal Investigator: John Hovanesian, MD

Sub Investigators: Behnaz Rouhani, MD, Karen Skvarna, OD, Isabell Choi-Siritaratiwat, OD

Reesha Alvarado, MSHI, COA, OSC
Clinical Research Coordinator
(949) 900-5248