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Research Studies at Harvard Eye Associates

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Light Adjustable Lens for Cataracts

New Clinical Study for Cataract Surgery

Ophthalmologists annually perform approximately three million cataract procedures in the US. Thanks largely to the growing number of individuals who have undergone successful LASIK surgery, patients now have higher expectations than ever for their vision after cataract extraction and lens implantation.

The Light-Adjustable Lens (LAL) by Calhoun Vision has the potential to provide patients with clear distance acuity without eyeglasses.

Harvard Eye Associates is one of just a few centers in the United States participating in a research study of the Light-Adjustable Lens Treatment for Cataracts. The Light-Adjustable Lens can be adjusted non-invasively after surgery using only a focused UV light from your surgeon. The goal is to give you the best possible vision without glasses.

Interested patients should contact:
Herman Bae BS, COA
Research Department at Harvard Eye Associates:

or 949-900-5248

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Raindrop™ Near Vision Inlay

Arms aren't long enough to read a menu?

You may be experiencing Presbyopia. This common vision change is a normal part of aging yet is a significant problem, especially for people who have excellent distance vision and now find themselves straining to see a computer screen and having to wear reading glasses. Harvard Eye Associates is participating in a clinical study to evaluate a new procedure that could improve your near and intermediate vision, and reduce or eliminate the need for reading glasses.

The Raindrop™ near vision inlay by ReVision Optics, Inc. (RVO) is a clear circular implant – like a tiny contact lens – that is implanted just beneath the surface of the eye. It is two millimeters in diameter (the size of a pinhead) and less than half the thickness of a human hair. The lens is designed so that it cannot be seen or felt once in place.

You may be a candidate if:

• You have trouble reading a newspaper or magazine without glasses

• You have difficulty with your close or intermediate vision (computer, cell phone, menu)

• You have good distance vision, but need reading glasses to see things up close

• You've never had eye surgery before

Qualifying candidates may be exempt from any charges. To find out more about this clinical study or to see if you are a candidate, at no charge, please call and speak with our study coordinator.

Interested patients should contact:
Herman Bae BS, COA
Research Department at Harvard Eye Associates:

or 949-900-5248

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Corneal Collagen Crosslinking (CXL) for Keratoconus and Ectasia

Riboflavin and UV Light to Strengthen the Cornea

We are pleased to announce that we are conducting a research study coordinated by the CXL-USA study group.

Harvard Eye Associates is now able to provide this state-of-the-art treatment to qualified patients. Collagen crosslinking (CXL) is a procedure that uses Riboflavin and UV light to help strengthen a weakened cornea and has proven effective in most cases for reducing or halting the progression of keratoconus. This procedure has enabled patients to achieve a more comfortable fit with their rigid gas permeable contact lenses and reduces the possibility of needing a corneal transplant. This clinical trial is designed to study the benefits and safety of corneal collagen crosslinking in patients with either keratoconus or corneal ectasia after previous refractive surgery.

Interested patients should contact:
Herman Bae BS, COA
Research Department at Harvard Eye Associates:

or 949-900-5248

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Sixth Generation CrystaLens® Implant

Lens Implant for Presbyopia and Astigmatism

The Crystalens® implant, which was first FDA approved in 2003, continues today to grow in popularity even over more recently released multifocal lens implant technologies. This increase in popularity is partly because, unlike other multifocal implants, the Crystalens® has undergone continuous redesign and improvement since its approval.

Each redesign of the Crystalens® has resulted in better depth of focus and quality of vision for patients. Harvard Eye Associates is one in a handful of centers in the US undertaking a trial seeking FDA approval of the newest, sixth generation Crystalens®, for correction of presbyopia and astigmatism.

You may be eligible to participate if you:

• Are at least 50 years of age
• Have corneal astigmatism
• Have a cataract in need of surgery
• Do not have any serious eye diseases
• Are not taking medicines for diabetes
• Have not had previous surgery in that eye

Interested patients should contact:
Herman Bae BS, COA
Research Department at Harvard Eye Associates:

or 949-900-5248

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Dry Eye Study

Dry eye is a chronic and debilitating ocular disease affecting over 25 million Americans. This number is expected to grow substantially in the next decade due to an aging population and increased incidence of type 2 diabetes, both of which contribute to higher rates of dry eye disease. 

Sonata (Lifitegrast 5.0% Ophthalmic Solution) is an innovative new medication designed to not only treat symptoms of irritation and dryness, but treats the underlying inflammation caused to your corneal surface surface by chronically dry eyes.

Interested patients should contact:
Herman Bae BS, COA
Research Department at Harvard Eye Associates:

or 949-900-5248

John A. Hovanesian, MD, FACS,
Principal Investigator
Roger V. Ohanesian, MD, FACS,
Associate Investigator

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Dry Eye Treatment Study - LipiFlow Thermal Pulsation

Are you suffering from Dry Eyes?

The LipiFlow Thermal Pulsation System (www.tearscience.com) is a service to help people suffering from dry eye, offering a significant technological shift in evaporative dry eye treatment by effectively relieving blockage of the eyelid glands during an in-office treatment. Opening the blocked eyelid glands allows the body to resume the natural production of lipids (oils) needed for the tear film. 70% of what causes Evaporative Dry Eye disease (also known as meibomian gland dysfunction) is evaporative or lipid deficient dry eye. Common dry eye symptoms include:

• dryness tearing
• discomfort and irritation sensitivity to light
• grittiness discharge
• feeling of foreign body in eye tiredness
• burning or stinging sensation itching
• vision disturbance redness
  

To find out whether you can benefit from the LipiFlow treatment, and participate in our research study, please:

1. Download and complete our Dry Eye Symptom Questionnaire.
2. Save the completed questionnaire to your computer.
3. "Click to Send" (only works with some browsers).

OR (if "Click to Send" doesn't appear functional):
3. Click on the link below and send the questionnaire as an attachment to:

Herman Bae BS, COA
Research Department at Harvard Eye Associates:

Questions? Please call: 949-900-5248

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CentraSight™ and the Telescope Implant

End-Stage Age-related Macular Degeneration?

The CentraSight™ treatment program uses a tiny telescope, an FDA-approved medical device, which is implanted inside the eye to improve vision and quality of life for individuals affected by End-Stage AMD, the most advanced form of Age-related macular degeneration (AMD), a disease of the retina and the leading cause of irreversible vision loss and legal blindness in individuals over the age of 65.

The CentraSight™ telescope implant, about the size of a pea, is intended to improve distance and near vision in people who have lost central vision in both eyes because of End-Stage AMD. The telescope implant is surgically placed inside one eye. The implanted eye provides central vision; the other eye provides peripheral vision. Read more about CentraSight™ and the Telescope Implant.

Interested patients should contact:
Herman Bae BS, COA
Research Department at Harvard Eye Associates:

or 949-900-5248

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Visiogen Intraocular Lens Implant

Lens Implant for Presbyopia

We are conducting a clinical research study to evaluate the safety and effectiveness of a new investigational intraocular lens.

This lens is being studied in cataract patients to evaluate the potential for both near and far vision. There are multiple test sites in the United States. Ours is one of several sites in California.

You may be eligible to participate if you:

• Are at least 50 years of age
• Have a cataract in need of surgery
• Do not have any serious eye diseases
• Are not taking medicines for diabetes
• Have not had previous surgery in that eye

Interested patients should contact:
Herman Bae BS, COA
Research Department at Harvard Eye Associates:

or 949-900-5248

Edward Kim, MD, MPH, FACS,
Principle Investigator

Our Promise

As always, Harvard Eye is first and foremost concerned about what is best for each individual patient. Call us today for your personalized consultation!

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Harvard Eye Associates Laguna Hills Office Map and Directions 24401 Calle de la Louisa Suites 300-312 Laguna Hills, California 92653 949-951-2020 FAX: 949-356-1660

Harvard Eye Associates San Clemente Office Map and Directions 665 Camino de los Mares Suites 102-103 San Clemente, California 92673 949-493-5411 FAX: 949-356-1660

The eye doctors of Harvard Eye Associates perform advanced technology diagnostic testing and treatment, as well as taking the time necessary to provide each patient with information needed to fully understand his or her condition and to achieve the best possible visual outcome.

If you or a family member or friend have not had a recent routine eye examination, have a specific eye condition that needs addressing, or are looking for an eye specialist, second opinion, or professional eye consultant please take a moment to Request an Appointment.